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Their efficacy and pharmacokinetic advantages have been repeatedly demonstrated, clinical translation is limited by uncertainties around cytotoxicity, immunogenicity, and long-term accumulation

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Given that these reducing equivalents are indispensable for cellular redox homeostasis and energy metabolism, an imbalance of the redox state of these molecules is implicated in a variety of pathological conditions, such as cardiovascular diseases, neurodegenerative diseases, cancer, and aging (10, 115)

In vitro studies of PBDE toxicity in two marine mammals have been reported

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