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Disclosures: Wesley Dixon: Nothing to Disclose, Shaun Chandna: Calliditas Therapeutics (previously Genkyotex): Grant/Research Support, Mirum Pharmaceuticals: Grant/Research Support, Lipocine: Grant/Research Support, Arrowhead Pharmaceuticals: Grant/Research Support, Stephen Zucker: Nothing to Disclose, Jordan Sack: Nothing to Disclose 1830 LOSS OF BAP1 CONFERS RESISTANCE TO FERROPTOSIS AND PROMOTES CHOLANGIOCARCINOMA DEVELOPMENT Peyton Classon 1 Sophia Jaramillo 1 Danielle Carlson 1 Irene Yan 2 Sumera Ilyas 1 Rory Smoot 1 Gregory Gores 1 Tushar Patel 2 Davide Povero 1 , 1 Mayo Clinic Rochester, 2 Mayo Clinic Florida Background: Cholangiocarcinoma (CCA) is a lethal epithelial cell malignancy of the biliary tract

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It has also been linked in some studies to improvements in arterial stiffness, lipid profiles, and endothelial function

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Regulation of gene expression by hypertonicity