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For oral GHK-Cu, the bioavailability is generally lower than with injections or IV administration because digestive enzymes and stomach acid break down peptides

Additionally, smoking while pregnant may cause this condition in children

In parallel, efforts are underway to identify early biomarkers, including those based on cerebrospinal fluid (CSF), peripheral blood, imaging modalities, and multi-omic signatures, to enable earlier intervention, before extensive neuronal loss has occurred

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