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In palmitic acid (PA)-induced human HCC cells, HepG2, leptin levels, and concentrations of inflammatory cytokines, including TNF- and IL-6, were decreased [324]

So, B12 injections can last for one month with slow release into the blood. In contrast, an IV (intravenous) infusion gives you the dose immediately so that you get the benefits immediately, and the effects are shorter lived

J Pediatr 163(6):15851591.e9

Tail vein blood (~5-10 l) was collected serially at 0, 30, 60, 90 and 120 min post-challenge through the tail-nick method (19) The blood collection procedure was approved by the Institutional Animal Care and Use Committee of City of Hope in accordance with the NIH Guidelines for Survival Blood Collection in Mice and Rats ( Blood glucose concentration was measured with an Accu-Chek Compact Plus glucometer (Roche Diagnostics Ltd.)

Henry says the same is true for cats in a home environment, which many cat owners do not realize