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Proc Am Assoc Cancer Res 45, 2004

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doi: 10.14218/JCTH.2024.00135 5 BauschDPauschTKraussT

b , Models were tested in four independent cohorts (Covance, LonGenity, Stanford-ADRC, SAMS)

Mutations are introduced into genes encoding key enzymes in C1 metabolism, most notably cystathionine beta-synthase (CBS), which converts homocysteine to cystathionine in a vitamin B6-dependent manner [2, 131]