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10.1016/j.chembiol.2019.03.016 2 ByunD

These changes occur concurrently with elevated myelin proteins and -syn accumulation, beginning during the prodromal motor stages (Figure 2C) [238]

Aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, is controlled by retinoic acid and plays a crucial role of aldehyde dehydrogenase enzymes in the survival of dopaminergic neurons by controlling the ALDH1A1 enzyme in PD (103)