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Health and sports officials are concerned about the increasing number of athletes utilizing ergogenic aids and nutritional supplements

Pan et al., 2007)

Nakatani, S

For instance, through DNMT3B, methylglyoxal (MG), a byproduct of glycolysis, can cause hypermethylation of tumor suppressor genes in breast cancer [55], demonstrating that metabolites act as epigenetic messengers. It is unclear, nevertheless, whether MG controls DNMTs in TC (especially the BRAF V600E mutant subtype) via a comparable mechanism, causing essential tumor suppressor genes, such as RASSF1A or PTEN, to become hypermethylated and promoting dedifferentiation and treatment resistance

JiaJDouPGaoMKongXLiCLiuZet alAssessment of causal direction between gut microbiotadependent metabolites and cardiometabolic health: a bidirectional Mendelian randomization analysis