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Moreover, molecular subtype discordances and changes, as well as genetic heterogeneity between the primary BC and BCBM, can significantly influence treatment and prognosis, 77 limiting the potential efficacy of targeted therapies that are based on the analysis of the primary tumour

Impairment of mitophagy allows the accumulation of faulty mitochondria, contributing to cellular quality control failure and accelerating disease progression [9]

2020 Apr 28;14(4):4890-4904

E.GirardinS

Another research group also built a library of ionizable LNPs for in utero mRNA delivery to mouse fetuses that resulted in the accumulation with the livers, lungs, and intestines with higher efficiency and safety as opposed to DLin-MC3-DMA and jetPEI -based delivery systems (Riley et al., 2021)