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7 (Suppl):S168-74 13

Dysfunction of MCUC increases calcium ion concentration in the endoplasmic reticulum, promoting vasoconstriction and mitochondrial fission while simultaneously reducing calcium concentration within the mitochondria and inhibiting calcium-dependent metabolic enzymes, thereby suppressing oxidative metabolism [102]

The highest incidence and fatality rates are found in East Asia and Southern Sub-Saharan Africa [124]

Biochem J (1966) 101(3):792810

Amino acid metabolism Amino acid metabolism, which can affect cancer cell status and systemic metabolism through energy metabolism and signal transduction, is deregulated in PDAC [47]