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Takahashi R, Kanda T, Komatsu M, Itoh T, Minakuchi H, Urai H, Kuroita T, Shigaki S, Tsukamoto T, Higuchi N, Ikeda M, Yamanaka R, Yoshimura N, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Wakino S, Itoh H (2022) The significance of NAD + metabolites and nicotinamide N -methyltransferase in chronic kidney disease

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Another randomized controlled trial assessed the effects of microencapsulated sodium butyrate (1.5 g/day for 12 weeks) in 52 patients with type 2 diabetes mellitus (T2DM) and abdominal pain

The synergy argument is therefore mechanistic extrapolation reasoning from what each does separately to what they might do together