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Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity

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CRISPR-based genetic screens combined with metabolic perturbations are systematically identifying synthetic lethal interactions in NSCLC cells with different genetic backgrounds, providing a roadmap for rational combination therapies [82]

HH-associated arthritis affects the second to fifth metacarpophalangeal joints or bilateral large joints (radiocarpal, elbow, hip, knee and ankle joints) eight times more often than other types of arthritis