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Moreover, several studies have demonstrated that the metabolic transition from OXPHOS to aerobic glycolysis mediated by Akt-mTOR-HIF-1 is the metabolic basis of TI (102, 116, 117) ( Figure 3 )

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Kiefer CM, Hou C, Little JA, Dean A

Collectively, these trajectory analyses revealed that Lserine fundamentally reprogrammed the metabolic state of IL7R low naive CD4 T cells, and CD4 T cells were moving from a developmental bottleneck toward a functionally competent state, with potential implications for overall immune balance in patients with ASD