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Energy stress activates LKB1-dependent AMPK, which phosphorylates downstream TSC2, then promotes the formation of the TSC1/TSC2 complex, and further inhibits the activity of mTORC1 [30]

[DOI] [PMC free article] [PubMed] [Google Scholar] Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L