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Secondary objectives included determining the efficacy and safety of the combination of nivolumab plus ipilimumab in patients with RMC, with efficacy measured by overall survival (OS), progression-free survival (PFS), time to ORR, duration of response, and the disease control rate (DCR)

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Exposure to folate receptor alpha antibodies during gestation and weaning leads to severe behavioral deficits in rats: a pilot study

A notable example is the fusion protein abatacept (Orencia) for arthritis, where C220S/C226S/C229S/P238S mutations in the linked Fc moiety led to significant decrease of cytotoxicity associated with CDC and ADCC 37