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Comhair, Emmea Cleggett-Mattox, Deepa George, Marcelle Baaklini, and Daniel Laskowski

Research published in peer-reviewed journals suggests the compound may interact with the nitric oxide (NO) system, which plays a central role in vascular regulation and tissue repair mechanisms

Abbreviations SNO: S -Nitrosylation NO: Nitric oxide PTM: Post-translational modification GO: Gene ontology KEGG: Kyoto Encyclopedia of Genes and Genomes Cys: Cysteine GSNOR: S -Nitrosoglutathione reductase GSNO: S -Nitrosoglyceathione SNP: Sodium nitroprusside GSH: Glutathione Trx: Thioredoxin BST: Biotin switch technique HPDP: N -[6-(Biotinamido)hexyl]-3-(2-pyridyldithio) propionamide IBP: Irreversible biotinylation program CysPAT: Cys-phosphonate labeling OxcyscPILOT: Oxidative Cys selective cPILOT SNO-RAC: SNO-resin-assisted capture TPS: Thiopropyl sepharose SILAC: Stable isotope labeling by amino acids in cell culture TMT: Tandem mass labels SNOSID: SNO Cys site identification nLC-MS/MS: Nanoflow liquid chromatography tandem mass spectrometry ICAT: Isotope coded affinity tag FluoroTRAQ: Fluorescent solid-phase resin with iTRAQ labeling ISA: IodoTMT switch assay DMPO: 5,5-Dimethyl-1-pyrroline n -oxide nESI-MS: Nano spray electrospray ionization mass spectrometry FLIp: FLICE inhibitory proteins Cav-1: Caveolin-1 VEGFD: Vascular endothelial growth factor D PRDX2: Peroxiredoxin-2 HDAC6: Histone deacetylase 6 protein TRAP1: Tumor necrosis factor receptor associated protein 1 FAK1: Focal adhesion kinase-1 DNMT3B: DNA methyltransferase 3B LTBP1: Latent TGF- binding proteins 1 HIF1: Hypoxia-inducible factor 1-alpha ESR2: E2estrogen receptor TOP2A: Topoisomerase II protein VCAM-1: Vascular cell adhesion molecule-1 CaN: Calcineurin phosphatase c-Src: Tyrosine kinase c-Src HB: Hemoglobin GTN: Glyceryl trinitrate AGT: O 6 alkylguanine DNA alkyltransfer SDH: Succinate dehydrogenase PHD2: Prolyl hydroxylase-2 MKP-1: Mitogen activated protein kinase phosphatase-1 TRAIL: TNF related apoptosis inducing ligands PFKM: Phosphofructose kinase AR: Androgen receptor ITG 6: Integrin 6 CSF1R: Colony stimulating factor 1 receptor References Hays E, Bonavida B

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