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Such an interpretation extends the horizons of the study of heritable anomalies of the connective tissues to a series of bridging phenotypes filling the gap between true HCTDs and (apparently isolated) functional somatic syndromes, such as fibromyalgia, chronic fatigue syndrome, and functional gastrointestinal disorder(s)

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470 Defective succinyl-CoA ligase not only hinders the TCA cycle by blocking the conversion of succinyl-CoA but also interferes with mitochondrial nucleotide salvage pathways by disrupting interactions with mitochondrial nucleotide diphosphate kinase, resulting in both metabolic dysfunction and mtDNA depletion

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