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doi: 10.1007/s12602-025-10707-y 455 RoySDhaneshwarS

That is why patients experience not only anemia, but also low vitality, poor growth, reduced exercise tolerance, organ stress, and diminished overall life force

System Xc- is a heterodimeric complex composed of the light chain SLC7A11 and the heavy chain SLC3A2, which mediates the 1:1 exchange of extracellular cystine for intracellular glutamate (Figure 2)