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Coppen, A., Brooksbank, B

Therefore, when compared to SC administration, IV or IM may not be the preferred approach for delivering high-dose mAbs therapies

In theory, combining them could offer complementary benefits

In addition, animals with simple metabolic abnormalities are difficult to show significant ED in a short time and may require additional interventions (such as vascular injury, drug induction), which further increases the difficulty and cost of modeling