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used LNPs formulated with DMAP-BLP to deliver GRIN1 siRNA, resulting in efficient silencing of neuronal gene expression in vitro and selective reduction of synaptic N -methyl-d-aspartate receptor (NMDAR) currents in the brain in mice through intracranial injection

By examining the interactions among various targets, researchers have identified key hub genessuch as ACHE, IL6, SLC6A4, and FOSthat are critical in the pathogenesis of depression treated with Chinese medicine [524]

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