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As illustrated in Figure 16.26 "Effect of Buffer Concentration on the Capacity of a Buffer", when NaOH is added to solutions that contain different concentrations of an acetic acid/sodium acetate buffer, the observed change in the pH of the buffer is inversely proportional to the concentration of the buffer

In the present study, a 6-h application duration was chosen to ensure better compliance

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Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, et al

Cluster RCTs : Instead of randomizing individuals, whole groups (e.g., schools, clinics, teams) are randomized, which is useful when individual randomization is impractical or risks contamination between groups