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Ferroptosis is closely associated with various liver disorders, including drug-induced liver injury, liver fibrosis, alcoholic liver injury, nonalcoholic fatty liver disease, hepatic ischemia-reperfusion injury, and liver cancer 44,45

The strategies in this protocol, in combination with physician supervised treatment, can provide a well-rounded approach to ensuring optimal kidney health

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

The decrease in the level of expression of genes responsible for the synthesis of superoxide dismutase increases with the increase in glutamine concentration