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Development 141 , 526537 (2014)

Combination therapies targeting multiple viral proteins can increase the genetic barrier to resistance, and all-oral, interferon-free regimens combining different classes of DAA are proving highly effective in treating chronic hepatitis C

In the transformation of hemorrhage after cerebral ischemia, iron overload significantly decreases oxidation metabolism, lactic acid generation, and brain pH value, further increasing iron release

Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes