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Radiation-induced anatomic changes during fractionated head & neck radiotherapy: a pilot study using an integrated CT LINAC system

J Neurochem (1999) 73(3):130917.10.1046/j.1471-4159.1999.0731309.x 12 PerierCTieuKGuganCCaspersenCJackson-LewisVCarelliVet alComplex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

The assay is based on detection of the fluorophore 7-amino-4-methylcoumarin (AMC) after cleavage from the labeled substrate LLVY-AMC

This multi-use capability is particularly valuable in in vivo rodent research requiring daily or twice-daily peptide administration across multi-week study durations, in dose-response studies requiring multiple concentration preparation from a single reconstituted stock, and in comparative pharmacology protocols requiring repeated access to multiple reconstituted compound vials simultaneously

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