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In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

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Classified as a growth hormonederived metabolic signaling peptide, AOD 9604 functions as a selective modulator of adipose tissue pathways, enabling targeted investigation of lipolysis without engagement of canonical growth hormone receptor signaling