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By revising the rates of AF-induced disease and the number of exposed populations it seems that the rule is an escape from AF-induced disease or tolerance to its toxic effect

This work was supported by grants from the National Natural Science Foundation of China (32250410298), the Science and Technology Planning Project of Shenzhen Municipality (KCXFZ20211020164543007 and 20210617155253001), the Foundation of Development and Reform Commission of Shenzhen Municipality (XMHT20220104028), the Guangdong Basic and Applied Basic Research Foundation (2021A1515012141) and the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (SZGSP013)

We defined HBV treatment success as undetectable HBV DNA or normal ALT at 12 months

Western Blotting The protein levels of dynamin-related protein (Drp)-1, fission protein (Fis)-1, phosphatase and tensin homolog induced putative kinase (Pink)-1, Parkin, optic atrophy (Opa)-1, light chain 3 microtubule-associated protein A/B (LC3A/B), manganese superoxide dismutase (MnSOD), translocase of outer membrane (Tom)-20 and OXPHOS complexes were measured by western blotting

At present, there is not a completely effective treatment for non responders patients, with a high mortality, so it is necessary to look for other therapeutic strategies