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The cationic polymer may contain from about 0.1 mol % to about 35 mol %, preferably from 0.2 mol % to about 20 mol %, more preferably from about 0.5 mol % to about 10 mol %, and most preferably from about 1 mol % to about 5 mol %, of the third, anionic structural unit

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A comprehensive understanding of the physiological properties of the BBB and how it alters under pathological conditions has also been investigated

Cluster 3 includes PTGS1, PTGS2 , and ALOX5 involved in prostaglandin metabolism and leukotriene receptor activity, whereas Cluster 4 ( MMP9, MMP2, ITGB8, LOX, TIMP2, and VCAM1 ) and Cluster 5 ( MMP9, MMP2, LOX, TIMP2 ) were found to trigger extracellular matrix organization, elastic fiber formation, and matrix metalloproteinases activity