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Pyroptosis of microglia after ICH may be the most critical initiator

Since the mitochondria within the liver cells primarily produce ketone bodies, utilizing ketones as a predominant fuel source means extra demand for this already-hardworking and overburdened organ

Curr Biomar Find 2:113 Yang X, Weng Z, Mendrick DL, Shi Q (2014) Circulating extracellular vesicles as a potential source of new biomarkers of drug-induced liver injury

According to Du et al., l-methionine sulfoximine (MSO) controls TAMs' glutamine metabolism and causes them to polarize toward the M1 phenotype [70] (Fig