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Arbutin (ARB) was found to reduce ROS, and MAD accumulation, upregulate GSH, and exert a mitigating effect on alcoholic fatty liver disease (ALD) and liver injury by modulating the Nrf2/HO-1 pathway and oxidative stress

Smith DR, Fedorka-Cray PJ, Mohan R , Brock KV, Wittum TE, Morley PS, Hoblet KH, Saif LJ

22 CAT mRNA level and its activity are usually upregulated when there is a disturbance in the oxidative status, particularly in H 2 O 2 levels

These observations also imply that nutrient supply, including dietary methionine or cysteine, could add to patient-to-patient variability in response to therapy targeting the MAT2A/PRMT5/MTAP axis and that combining MAT2A/PRMT5 inhibition with nutrient depletion could result in enhanced responses

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