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In addition, experiments combining increased concentrations of SAC and TMZ were carried out to investigate whether these compounds exert additive cytotoxic effects

Nature 465 , 243247 (2010)

Specifically, the expression levels of SA-related genes ( OsPR1a and OsWRKY45 ) and JA-related genes ( OsAOS2 and OsJAMYB ) were quantitatively analyzed under different treatment conditions

Although the direct epigenetic effects of CBD on NOS or Nrf2 signaling have not been fully elucidated, the overlap between CBDs redox and anti-inflammatory properties with epigenetically controlled pathways suggests a potential mechanistic connection