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It is imperative to explore novel strategies aimed at reducing MMA levels, considering the limited efficacy of B12 supplementation revealed by our findings

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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear

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