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As CoPP structurally mimics heme but cannot be efficiently degraded by HO-1, CoPP treatment has been proposed as a potential therapeutic strategy for oxidative stress-related diseases, including cardiovascular disease 65,66 , diabetes 67 , obesity 68 , septic insults 65 , and metabolic syndrome 69

Mechanistically, the 2-O-methyl group does not create insurmountable steric barriers to codonanticodon duplex formation

Future trials are needed to further investigate the role of GLP-1RA among patients with liver disease

There is no conclusive evidence that high B12 levels are intertwined with cancer

2025;48(1 Suppl 1):S181206