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Additionally, we used UCSC Genome Browser tracks for GRCh38 to identify potentially functional annotations not captured in the earlier VEP and ANNOVAR analyses, within +/-2.5 kb of the variant, a plausible effect window for short structural variants, tandem repeats, and transposable elements

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Increased accumulation and uncontrolled mitochondrial ROS generation can harm mitochondrial components, including proteins, membranes, and mtDNA, and induce mitochondrial quality control (MQC) [125,126,127]

Moreover, iron promoted IL-6 levels in CD11c + cells, thereby increasing the hepatic infiltration of neutrophils and promoting the inflammatory responses

Barratt RW, Johnson GB, Ogata WN