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Crosstalk through NLRP3 The NLRP3 inflammasome is a multi-protein complex that recognizes PAMPs or damage-related molecular patterns (DAMPs) and activates the protease caspase-1, leading to pyroptosis and the formation of mature IL-1 and IL-18 to mediate the inflammatory response (151)

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Welsh DJ, Peacock AJ

Because plasma tCys has been positively associated with fat mass in humans, we tested the hypothesis that decreased tCys in TgI278T Cbs / mice was the cause of the lean phenotype by placing the animals on water supplemented with N-acetyl cysteine (NAC) from birth to 240 days of age