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(52) Regular users of PPIs have a 44 percent increased risk of dementia compared to those who dont use the drugs

10.1016/j.freeradbiomed.2013.07.013 113 WenY.ChenH.ZhangL.WuM.ZhangF.YangD.et al (2021)

the gut microbiota, meanwhile, modulates immune homeostasis via the gut-brain axis, with its metabolites (e.g., short-chain fatty acids) enhancing BBB integrity and suppressing neuroinflammation through immunomodulation

But the body has mechanisms to combat excessive oxidative stress levels and resulting damage

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