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MS analysis was operated in positive polarity using two different runs: in the full MS scan mode first (for molecular average isotopic enrichments) and then in the AIF mode (All Ion Fragmentation

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Furthermore, CAF-derived exosomes, which carry acetic acid, lipids, amino acids, or TCA intermediates, are taken up by pancreatic cancer cells via macropinocytosis and are associated with the inhibition of mitochondrial oxidative phosphorylation and increased compensation of glycolysis

Cell proliferation pathways such as PI3K/AKT/mTOR and NF-B can further enhance anti-apoptotic systems, promoting tumor cell resistance to apoptosis