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10.3389/neuro.07.003.2009 76 FlemingS

Basu M, Prasad R, Jayamurthy P et al (2007) Anti-atherogenic effects of seabuckthorn ( Hippophaea rhamnoides ) seed oil

Furthermore, SFN may activate Nrf2 by initiating the transcription of trigger receptor expressed on myeloid cells-2 (TREM2) in the medial PFC (mPFC), increasing the expression of the M2 microglial marker arginase 1 (ARG1), which may alleviate depressive phenotypes through its anti-inflammatory and neuroprotective functions (He et al., 2022)

This increased ROS production is exacerbated by activation of the NADPH oxidase system and increased NADPH levels through the hexose monophosphate shunt, which supports ROS generation [144]

Carotenoid concentrations in your skin plummet, stripping away natural protection against oxidative damage