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H., Hassanzadeh, A., Shakeriankhoo, F., Hosseini, S

MCT1 is a low affinity, high capacity transporter that has been shown to transport unbranched aliphatic monocarboxylates such as acetate and proprionate and substituted monocarboxylates pyruvate, lactate, acetoacetate and -hydroxybutyrate, with the m values for pyruvate and lactate about 0.7 and 3-5 mM, respectively (Halestrap and Meredith 2004)

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Although the drug met its primary endpoint of achieving a statistically significant weight reduction compared to placebo, the results fell short of the 25% weight loss target that Novo had been pitching to investors

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