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Trials investigating melanotan 1 as an implant in skin disorders like erythropoietic protoporphyria (EPP) have applied the peptide as a 16mg implant every 60 days (8mg/month), for up to 6 implants a year (e.g

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The off-period gives baseline NNMT activity a chance to reset before the next cycle

Eur Rev Med Pharmacol Sci 2014