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Parkinsons disease PD is characterized by a gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of intracellular aggregates of misfolded -synuclein that causes motor dysfunction [124]

21 TABLE 3 Medications That Should Be Avoided By Persons with G6PD Deficiency* TABLE 5 Symptoms and Laboratory Evaluation in Patients with G6PD and Acute Hemolysis Drugs that cause hemolysis in G6PD-deficient persons inf lict oxidative damage to erythrocytes leading to erythrocyte destruction

Jayne, L

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However, the emergence of immunotherapy, targeted therapy vaccines, small molecule therapies, and combination therapies in recent years have offered hope in terms of both effectiveness and safety for treating melanoma (244)