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Nevertheless, acute exogenous oxytocin supplementation produced only a temporary prosocial effect [106, 107], likely due to short half-life of oxytocin in the brain [108, 109]

For this reason, an overdose is very rare and it's generally considered safe, even at high doses

A population pharmacokinetic and pharmacodynamic modelling approach to support the clinical development of RBP-6000, a new, subcutaneously injectable, long-acting, sustained-release formulation of buprenorphine, for the treatment of opioid dependence

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