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Esophageal irritation is another concern: swallow with a full glass of water and remain upright for 30 minutes

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Interactions with the development of serotonin syndrome or neuroleptic malignant syndrome have been described when trazodone is used concomitantly with drugs that have serotonergic activity, such as other antidepressants (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors, selective serotonin-norepinephrine reuptake inhibitors, and MAO inhibitors) and antipsychotics

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