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NSC48160, a Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitor, indirectly suppresses the NRF2-SLC7A11-GPX4 axis by disrupting the tricarboxylic acid (TCA) cycle, thereby promoting ferroptosis in KRAS-mutant HCC models [47]

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For one subject, the spectrum obtained at the second post-dose time point was of insufficient quality, and was omitted from analysis

Huang D, Wang Y, Thompson JW, Yin T, Alexander PB, Qin D

A series of mutants impaired in other genes putatively involved in glutathione homeostasis were however not more susceptible than WT