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Protective potential of pterostilbene against cyclophosphamide-induced nephrotoxicity and cystitis in rats

Arterial stiffness is characterized by structural (e.g., tunica media calcification, alterations in vascular smooth muscle cells, and fibrosis) and functional (e.g., loss of Windkessel function , elevated pulse pressure, and development of isolated systolic hypertension) vascular changes that cause microvascular dysfunction and end-organ damage (e.g., heart failure, vascular dementia, hypertensive retinopathy, and chronic kidney disease)

Among these, hsa-miR-124-3p warrants attention for its role in inhibiting synaptic plasticity by negatively regulating the cAMP-response element-binding protein (CREB) pathway and, consequently, serotonin-dependent synaptic facilitation (Liu et al., 2024)

Do not mix with strong exfoliating acids (AHA/BHA) or retinol in the same routine

A possible scenario is that Gclc deficiency causes a mild block at the TrB1 stage, possibly impacting the maturation of MZB precursors