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But even today, more than three decades after BPC-157 was first synthesized, a grand total of three human studies have been conducted, and none of them were the kind of large-scale human trial thats typically part of the traditional drug-approval process

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In a previous randomised, placebo-controlled trial, de Jager et al (2010) added metformin 850 mg three times daily to insulin therapy (a higher metformin dose than is usually now used) and demonstrated a number needed to harm of just under 14 for development of B12 deficiency over the 4.3 years of the trial