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Damage to the tubular endothelial cells can increase leukocyte adhesion, platelet aggregation, and vasoconstriction, reduce blood flow to nephrons, and damage the glomerular barrier and the extensive network of peritubular capillaries (88)

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Typically, before a drug can be marketed, it must pass through a series of clinical trials, in order to identify safe dosages and to determine that any positive outcomes are due to the substance itself, and not to bias in the study design

If peptides will be used immediately or within the next few days, weeks, or months, short-term refrigeration below 4C (39F) is generally acceptable