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At the same time, B12 insufficiency in the liver leads to shrinking of the intestinal cells and malabsorption of nutrients (including B12 itself), leading to a cycle of worsening B12 deficiency

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Vitamin B12, also known as cobalamin, is a water-soluble vitamin essential for: Red blood cell formation Nervous system health DNA synthesis Brain function Energy metabolism A lack of vitamin B12 can lead to symptoms such as fatigue, depression, and memory problems, and if left untreated, it may even cause lasting neurological damage

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When both nutrients are deficient, B12 should be initiated before or alongside folate to avoid worsening neurological symptoms