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Drug interactions are another significant challenge, as EGCG interacts with medications through various mechanisms, including effects on drug-metabolizing enzymes and transport proteins

In a study analyzing maternal mid-gestation (MMG) plasma at 18 weeks of gestation and umbilical cord blood plasma samples at birth, children that developed ASD later in their development exhibited metabolomic dysregulation, which is an accumulation of methionine levels in ASD children, among other metabolites [173], pointing to folate metabolism imbalances potentially diverting flux away from the formation of the S-adenosyl methionine (SAM) cofactor, which is essential for the methylation reactions that underpin epigenetic regulations [41]

Khavinson, V., Linkova, N., Diatlova, A., & Trofimova, S

modulating autophagy with natural compounds or repurposed drugs may inadvertently affect non-malignant tissues, given that autophagy is vital for normal cellular homeostasis, especially in the heart, liver, and immune system, organs that are already vulnerable to DOX toxicity

and De Paola, M