bacterial and host-derived glutathione are required to activate prfa Host is for Rickettsia parkeri properly septate, avoid ubiquitylation, survive in macrophages Discovery of a glutathione utilization
Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species ScienceDirect Allosteric GSH binding primes PrfA for DNA binding. (A and B) Download Scientific Diagram Structural basis of promiscuous inhibition of Listeria virulence activator PrfA by oligopeptides: Cell Reports Structural insights into glutathione mediated activation of the master regulator PrfA in Listeria monocytogenes Protein & Cell Springer Nature Link Diverse roles of low molecular weight thiol GSH in Francisella's virulence, location sensing and GSH stealing from host ScienceDirect
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