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A Mendelian randomization analysis based on large genome-wide association study (GWAS) demonstrated that genetic liability to schizophrenia is associated with an increased risk of all-cause dementia, AD, and VaD (96)

Notably, reactive astrocytes aberrantly produce GABA from putrescine via MAO-B, releasing it through the BEST1 channel 58,59

However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007)