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Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways

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Deficiency might stem from genetics or selenium lacks, amplifying age-related declines

The liver is the primary organ responsible for iron storage and regulation, making it highly susceptible to iron overload-induced injury [4]

This damage to the skin barrier at lesion sites intensifies the inflammatory response and worsens the severity of acne lesions